Notice: register_sidebar was called incorrectly. No id was set in the arguments array for the "Sidebar" sidebar. Defaulting to "sidebar-1". Manually set the id to "sidebar-1" to silence this notice and keep existing sidebar content. Please see Debugging in WordPress for more information. (This message was added in version 4.2.0.) in /data/30/1/121/80/1121895/user/1185656/htdocs/wordpress/wp-includes/functions.php on line 3622

Notice: add_custom_image_header is deprecated since version 3.4! Use add_theme_support( 'custom-header', $args ) instead. in /data/30/1/121/80/1121895/user/1185656/htdocs/wordpress/wp-includes/functions.php on line 3406

Notice: The called constructor method for WP_Widget is deprecated since version 4.3.0! Use
__construct()
instead. in /data/30/1/121/80/1121895/user/1185656/htdocs/wordpress/wp-includes/functions.php on line 3457
CurrentMedicine.tv » Early stoppage of clinical trials

Early stoppage of clinical trials

Dr. Guyatt explained in a previous post why early stoppage of clinical trials results in falsely inflated efficacy of the therapy being studied. The April 16, 2009 edition of The New England Journal of Medicine has a great example how Kaplan curves tend to converge with time and erase early efficacy differences. The study looked at the drug valsartan for the treatment of atrial fibrillation and failed to show a benefit over the comparator cohort(see graph). If it were stopped early, it would have shown that the drug was effective. Note the curves touching, or converging, as time progresses.

kaplan-curves-of-valsartan4

No Comments

No comments yet.


Notice: comments_rss_link is deprecated since version 2.5! Use post_comments_feed_link() instead. in /data/30/1/121/80/1121895/user/1185656/htdocs/wordpress/wp-includes/functions.php on line 3406
RSS feed for comments on this post. TrackBack URI

Leave a comment

WordPress Themes

hogan outlet calvin klein baratos calzoncillos calvin klein baratos calzoncillos calvin klein calzoncillos calvin klein ralph lauren canada cheap tiffany calzoncillos calvin klein baratos calvin klein baratos calzoncillos calvin klein calzoncillos calvin klein baratos calzoncillo Calvin Klein hogan outlet online hogan outlet outlet hogan sito ufficiale michael kors uk outlet